R&D
Intergen is a center established with the aim of patient service and R&D. We have ensured that all types of genetic testing are carried out at our center with over 90% of the materials and methods we produce.
R&D AT INTERGEN
INTERGEN IS A CENTER ESTABLISHED WITH THE OBJECTIVE OF PATIENT SERVICE AND R&D.
Since 1999, our slogan is “Human, Life and Science”
IN RARE DISEASES, IT MAY BE REQUIRED TO DEVELOP SPECIAL MATERIALS AND TEST METHODS FOR EACH PATIENT FREQUENTLY TO FIND AND DEFINE NEW DISEASES.
• We prevented dependence on abroad in diagnosis
• We have ensured that all types of genetic testing are carried out in our center with over 90% of the materials and methods we produce.
• Reducing addiction in new target therapy.
• With our teammates who have academic achievements,
• With more than 45 projects that we are currently carrying out with our resources,
• Receiving additional support, especially from TUBITAK
• With university and industry collaborations
• We are making progress in both basic science and patient service.
Our R&D unit;
• With more than 60,000 primers designed and the methods we developed
• We use our designs in 90% of the genetic tests of thousands of tests for 5500 diseases.
• When planning studies for our scientific project partners, we participate in the discussion with our young team by saying "EVEN", not "BUT".
• By contributing to the young friends who are inexperienced in the project, we ensure that they also benefit our country.
• We carry out our R&D activities not only to provide the highest quality healthcare service to our patients but also to represent our country abroad with products with high added value.
• We invest in people and knowledge by constantly increasing the budget we allocate for R&D activities.
• We don't just follow the developing technology, we direct it.
OUR R&D SUPPORT SERVICES
We support the projects of other institutions with almost all genetic testing techniques, especially the following techniques.
1- Whole Exome Sequencing (WES)
One of the most comprehensive methods for diagnosing genetic diseases is Whole Exom Sequencing. With this method, all coding DNA regions of approximately 20000 genes in the human genome are sequenced and changes that may be associated with diseases are detected. This approach is a method that is used when the gene regions to be sequenced are not clear or are too many, allowing to give fast, reliable, and accessible results. This method is used in our center for research conducted in non-human samples, provided that there is a ready-made kit in the market.
2- Whole Genome Sequencing (WGS)
In some cases intended for the diagnosis of genetic diseases, sequencing of the entire genome is required. In this case, the sequence of 3 billion bases in the human genome is done and the clinical condition of the patient is clarified with the analyzing.
This method is used in our center for research on non-human samples.
3- Sanger Sequencing
With the Sanger Sequencing method, which is the Gold Standard of sequencing technologies, we carry out our work at every step from the design stage of our scientific studies to the analysis of the results. We contribute to the science of our country with our device infrastructure and our solutions.
We carry out our work in our center at different points, from the PCR stage, which is the starting point of your work, to the Capillary Electrophoresis stage, where the sequence data is obtained, and the data we obtained together with our Bioinformatics team.
In addition to Sanger sequencing; Fragment Analysis, Genotyping, and Quantitative studies are the methods we use in our R&D projects.
This method is used in our center for research on non-human samples.
Special material design is made for the project.
4- Next Generation Sequencing (NGS)
Next Generation Sequencing (NGS) is a breakthrough technology that allows a large number of samples to be sequenced together. As Intergen, we use sequencing alternatives at different scales in our R&D projects for projects of different sizes.
This method is used in our center for research on non-human samples.
Special material design is made for the project.
5- Methylation Studies
When it is required to carry out research with this method in genes where methylation is effective, support is provided with methylation-specific PCR, Array, and methylome studies.
This method is used in our center for research on non-human samples.
Special material design is made for the project.
6- Real-Time PCR Applications (TaqMan, SYBR Green)
• Genotyping
• Gene expression determination
This method is used in our center for research on non-human samples.
Special material design is made for the project.
7- Cloning
• Vector design
• TA cloning
• Gibson cloning
8- Cell-Free Protein Synthesis